Which statement is NOT part of the recovery process from neuropraxia due to demyelination?

• A. Remyelination of inter-nodal membrane
• B. Axonal degeneration occurs
• C. De novo synthesis of new sodium channels into inter-nodal membrane
• D. Recovery involves restoration of conduction with remyelination

Answer: (B)

Neuropraxia from demyelination blocks conduction without damaging the axon itself. Recovery happens as the myelin sheath is repaired (remyelination) by Schwann cells, which restores saltatory conduction along the fiber. As the internodal membrane is remyelinated, the axon also re-establishes proper ion channel distribution, including the de novo synthesis of sodium channels into the inter-nodal membrane to re-form functional nodes of Ranvier. Restoring conduction with remyelination is exactly what recovery looks like in this scenario. In contrast, axonal degeneration would mean the axon itself is damaged and would require regrowth along the axon, which is not part of the recovery process for neuropraxia due to demyelination.